失去工作对他的自信心是一个严重的打击。

Losing his job was a severe ___blow to his confidence.

这个消息对他来说是个巨大的打击，以至于他无法接受。

The news was such a great ___blow for him that he couldn't process it.

他导师的突然去世对他的职业生涯是一个毁灭性的打击。

The sudden death of his mentor was a devastating ___blow to his career.