She sold the house even though it was against his wishes.

against 是介词，意思是"反对、违背"，表示与某事物对立或相反。 his 是代词 he 的所有格形式，意思是"他的"，表示所属关系。 wishes 是名词 wish 的复数形式，意思是"愿望、意愿"。 against his wishes 这个短语表示"违背他的意愿"，指做某件事与对方的愿望相冲突。