跑完马拉松后，他开始明显感到疲劳。

After running the marathon, he began to ___tire visibly.

冗长的会议总是让我精疲力尽；之后我需要休息一下。

Long meetings always ___tire me out; I need a break afterwards.

变换你的演示主题，以免让你的听众感到厌倦。

Vary your presentation topics to avoid ___tiring your audience.