他不顾医生的建议，飞往了那里。

He flew there ___against his doctor's advice.

她不顾团队的明确意愿，继续推进这个项目。

She continued the project ___against the explicit wishes of her team.

这位年轻的运动员不顾父母的建议参加了比赛，决心证明自己。

The young athlete competed ___against her parents' advice, determined to prove herself.