我一整天都感觉非常不舒服，所以早早就上床睡觉了。

I'd been feeling ___wretched all day so I went to bed early.

结果，一些人会意识到他们年轻时未能实现目标，并会感到非常不开心。

As a result, some people will realise they were unable to achieve their ends when they were younger and will feel ___wretched.

毁灭性的消息之后，她显得极其悲惨，将自己与他人隔绝开来。

After the devastating news, she appeared utterly ___wretched and isolated herself from others.