在疾病的后期阶段，它会导致失明。

In its later stages the disease causes ___blindness.

除了失明之外，他的整体健康状况也恶化了。

Apart from his ___blindness, his health has worsened in general.

那次事故导致了永久性失明，这严重影响了他的职业生涯。

The accident resulted in permanent ___blindness, which severely impacted his career.