吸烟对他的肺部造成了不可逆的损伤。

Smoking has caused ___irreversible damage to his lungs.

重要的是要记住，任何事做得过度都可能产生不可逆的后果！

It is important to remember that everything done excessively can have ___irreversible consequences!

关闭工厂的决定是不可逆的。

The decision to close the factory is ___irreversible.