又一次失败后，一阵深深的绝望感席卷了他。

After another failed attempt, a profound sense of ___despair washed over him.

当我们所有的计划都落空时，我们陷入了绝望的深渊。

When all our plans fell through, we were left in the depths of ___despair.

盯着空白的稿纸，她对于能否完成小说感到一阵悄然袭来的绝望。

Staring at the blank page, she felt a creeping sense of ___despair about ever finishing her novel.