我的家庭责任包括照顾我的弟弟妹妹。

My family ___commitments include taking care of my younger siblings.

由于我的工作事务，我将无法参加本周末的聚会。

Due to my work ___commitments, I won't be able to attend the party this weekend.

同时应付多项事务可能很有挑战性。

Juggling multiple ___commitments can be challenging.