他的疾病实际上结束了他的职业生涯。

His illness ___effectively ended his career.

在美国，西班牙语实际上是第二交流语言。

In the US, Spanish is ___effectively the second language of communication.

新规定实际上阻止了该地区的任何进一步发展。

The new regulations ___effectively prevent any further development in the area.