该地区以其极端天气条件而闻名。

The region is known for its ___extreme weather conditions.

在极端情况下，这种疾病可能导致永久性失明。

In ___extreme cases, the disease can lead to permanent blindness.

这似乎是一个极端案例，但它凸显了现代童年时期的一个真实问题。

It seems to be an ___extreme case, but it highlights a real issue with modern childhood.