遗憾的是，这种治疗方法并不对所有患者都有效。

___Sadly, the treatment doesn't work for all patients.

如果你认为她会让你那样做，那你就大错特错了。

If you think she'll let you do that, you're ___sadly mistaken.

几十年前流行的一些娱乐形式，遗憾地，已经消失了。

Some forms of entertainment which were popular decades ago have, ___sadly, disappeared.