这是一个难以掌握的科目。

It's a difficult subject to ___get ___to ___grips ___with.

因此，他们每天面对紧张的时间表，必须应对为学校准备的繁重工作。

As a result, they are daily faced with tight schedules and they have to ___come ___to ___grips ___with the demanding work they have to prepare for school.

他努力掌握新软件。

He struggled to ___come ___to ___grips ___with the new software.