新经理将于下周上任负责。

The new manager will ___take ___charge next week.

事件发生后，政府决定负责调查工作。

After the incident, the government decided to ___take ___charge of the investigation.

在紧急情况下，需要有人负责并给出明确的指示。

In an emergency, someone needs to ___take ___charge and give clear instructions.