这个故事结局悲惨。

The story ended ___tragically.

可悲的是，这种药物的副作用被发现得太晚了。

___Tragically, the drug's side effects were discovered too late.

她短暂恢复健康后，病情又急剧恶化。

Her brief return to health was followed by a ___tragically sudden decline.